Oxidative stress in type 2 Diabetes mellitus: its importance in the management of patients

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  • Lectures1 Video
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Key concepts covered include:

An Overview of:

  • An introduction to oxidative stress and reactive oxygen species (ROS)
  • Oxidative stress as a result of normal metabolic processes in the human body
  • Normal physiological handling of oxidative stress in the human body
  • Metabolic derangements resulting in increased oxidative stress in diabetes
  • oxidative stress leading to secondary complications common in diabetes affecting the quality of life of patients with diabetes
  • Evaluation of oxidative stress parameters in patients with diabetes (What to look for in chemical pathological investigations)

What you'll learn

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia with associated distortions in nutrient metabolism particularly of carbohydrate, protein, and lipid which results from the body’s inability to produce insulin or use insulin to its full potential It is a lifelong progressive metabolic disorder requiring appropriate treatment, control measures, and monitoring failing which can lead to severe disabling secondary complications increasing the disease burden in any country irrespective of the soundness of the health system. read more »»

Though diabetes does not differentiate between caste, creed, or political affiliation it sure follows a difference in its urban-rural distribution. In 2019 more people with diabetes live in urban (312.3 million) than in rural (152.6 million) areas. The prevalence in urban areas is 10.8% & rural 7.2%. The number of people with diabetes is expected to increase to 415.4million in 2030 and 538.8million in 2045 as a result of global urbanization. This equates to a prevalence of 11.9% in 2030 and 12.5% in 2045.

As a consequence of chronic hyperglycemia and insulin resistance, various long-term complications develop which include both micro and macrovascular complications. These include retinopathy with loss of vision, peripheral neuropathy with risk of amputation, autonomic neuropathy causing gastrointestinal, genitourinary, and cardiovascular symptoms and nephropathy causing renal failure. The development of disabling chronic complications of diabetes mellitus has been attributed to oxidative stress. Oxidative stress results due to chronic hyperglycemia, dyslipidemia, and elevated fatty acids in circulation.

Who should attend?
Physicians and health care specialists involved in the management of patients with type 2 diabetes

Instructor

Prof. Grace George

Retired Professor, Faculty of Health Sciences, Walter Sisulu University, South Africa


4/5

George G completed her Ph.D. in 1980 from Central Food Technological Research Institute, Mysore. India. Currently, she is working as a Professor and Head of the Division of Medical Biochemistry, Faculty of Health Sciences at Walter Sisulu University, South Africa. Many Post-graduate students graduated under her supervision and she has several publications and presentations to her credit.

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Instructor

Prof. Grace George

Retired Professor, Faculty of Health Sciences, Walter Sisulu University, South Africa


4/5

George G completed her Ph.D. in 1980 from Central Food Technological Research Institute, Mysore. India. Currently, she is working as a Professor and Head of the Division of Medical Biochemistry, Faculty of Health Sciences at Walter Sisulu University, South Africa. Many Post-graduate students graduated under her supervision and she has several publications and presentations to her credit.

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Last Updated 04/2021

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