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Skill Levelintermediate
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Enrolled 1,207 students enrolled
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Key concepts covered include:
By the end of this module, you should be able to:
- Focus on CDK4 and 6 as key regulators of the G1- S transition of the cell cycle.
- Acknowledge that an array of substrates for CDK4 and 6 have been identified, including the retinoblastoma protein, RB1, which can potentially lead to drug target discovery.
- Describe the mechanisms and clinical implications of endocrine resistance.
- Define an evidence-based algorithm for the management of hormone-positive breast cancer progressing on endocrine therapy.
- Define a differential algorithm for primary and secondary endocrine-resistant breast carcinoma.
- Establish a paradigmatic sequential path of clinical utility to drive therapeutic decision-making of your working group.
- Illustrate the hypothetical role of CDK4/6 inhibitors in the neoadjuvant and adjuvant settings of care.
- Assess adequately and treat early the preventable adverse events of CDK4/6 inhibitors with a special focus on neutropenia.
- Explain the clinical benefit of CDK 4/6 inhibitors.
- Learn how to manage the side effects of CDK4/6 inhibitors.
- Be aware of adverse events and challenges.
- Share your knowledge with your oncology team and your patients.
What you'll learn
This course is a collection of modules on breast cancer CDK 4/6 inhibition, developed to support the professional development of three distinct healthcare professions.
Curriculum
Last Updated 07/2021